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Los Trece de la Fama.

Esta es la segunda parte del Blog " Paracelso tenía razón" http://drlopezcorbalan.blogspot.com/ Como decía  Fray Luis de León...

jueves, 26 de diciembre de 2019

Cannabinoide JWH 307 detectado en Alemania.




Primera aparición en Alemania del JWH-307 y recurrencia del JWH 018.

Son los cannabinoides sintéticos que forman parte de las hierbas tipo " Spice". Una noticia que no sorprende a nadie puesto que las " hierbas" euforizantes no están  específicamente prohibidas, al emnos  no sometidas a fiscalización.



 El trabajo está  publicado en 


Aquí tienen el artículo en su versión original. 


Abstract

Herbal smoking blends, available on the German market were analyzed and several known synthetic cannabinoids were identified (JWH-122 and JWH-018).
In addition, we isolated a new active ingredient by silica gel column chromatography and elucidated the structure by nuclear magnetic resonance (NMR) methods. The compound was identified as JWH-307, a synthetic cannabinoid of the phenyl-pyrrole subclass with known in vitro binding affinities for cannabinoid receptors. To date, this is the first appearance of this subclass of cannabimimetics in such products. JWH-307 has been further characterized by gas chromatography accurate mass spectrometry (GC–HRMS), electrospray tandem mass spectrometry (ESI-MS/MS), ultraviolet (UV) and infrared (IR) spectroscopy.
JWH-018 was among the first compounds banned by many countries world-wide including Germany. The identification of JWH-018 was striking, since this is the first report where JWH-018 recurred on the German market thus violating existing laws.
A generic method was established to quantify synthetic cannabinoids in herbal smoking blends. Quantification was achieved using an isotopically labeled standard (JWH-018-D3). JWH-018 was found at a level of 150 mg/g while JWH-122 and JWH-307 occurred as a mixture at a total level of 232 mg/gP7